Consult your veterinarian before administering to sick or pregnant animals. Tablets for removal of E. multilocularis is the same as that indicated for the removal of the other tapeworm species listed on the label. Laboratory efficacy studies conducted with Drontal Plus tablets have demonstrated the recommended dosage is 100% effective. No drug-related abnormalities in clinical pathology parameters were identified. Do not crush or chew the praziquantel tablet or portion of a tablet. Swallow the pill whole. Take pyrantel exactly as directed by your doctor or as directed in the package labeling. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
Biltricide praziquantel is an anthelmintic, or anti-worm, medication used to treat infections caused by Schistosoma worms, which enter the body through skin that has come into contact with contaminated water. Schistosoma worms are found in Africa, South America, Middle Eastern countries, the Carribean, and parts of Asia. Biltricide is also used to treat infection with liver flukes, caused by a type of worm found in East Asia. How should I take praziquantel? Campbell WC. 1986. The Chemotherapy of Parasitic Infections. J. Parasit.
Tapeworms Dipylidium caninum, Taenia taeniaeformis Hookworms Ancylostoma tubaeforme and Large Roundworms Toxocara cati in cats and kittens. An injection site study conducted in pigs demonstrated that the formulation may induce a transient reaction in the subcutaneous tissue. No painful responses to administration were observed. United States. Data indicates most cats are cleared of their parasite infections within 7 days of treatment. These studies demonstrated Drontal Tablets are safe and efficacious for the removal of the parasite species indicated on the label when used as directed.
Local irritation or swelling at the site of subcutaneous injections have been reported for cats. Assistance in the diagnosis of E. multilocularis may be available from a state veterinary diagnostic laboratory. Additional information on the life cycle and epidemiology of this parasite is available in veterinary parasitology texts. Hookworms are small whitish or reddish-brown worms less than one inch in length that live in the intestinal tract and feed on blood. Cats can become infected with hookworms by swallowing infected larvae while grooming or when larvae from the environment burrow through the skin. Cats infected with hookworms may have poor physical condition, dull haircoat, and reduced body weight and diarrhea, sometimes with the presence of dark blood.
To prevent reinfection, toilets must be disinfected daily, and clothing, linens, towels, and pajamas must be changed and washed daily. Echinococcus multilocularisis a tapeworm species usually found in wild canids, including foxes, coyotes and wolves. The parasite has also been identified in domestic dogs and cats and is potentially a serious public health concern because it may infect humans. Use caution when driving, operating machinery, or performing other hazardous activities. Pyrantel may cause dizziness. If you experience dizziness, avoid these activities. The daily dose has been given in 3 divided doses. Do not drive or operate heavy machinery on the day of and during the 24 hours after treatment; the drug may cause dizziness or drowsiness. Tell your doctor all medications you use. During pregnancy, Biltricide should be used only when prescribed. This drug passes into breast milk. Breastfeeding while using this drug is not recommended. Nursing mothers should stop breastfeeding on the day of treatment and for 72 hours after taking the last dose. Use with caution in sick or debilitated cats. Oral ingestion or exposure should be avoided. Use with caution in heartworm positive cats. The cats enrolled in the field study were heartworm antigen and antibody negative prior to entering the study. In a laboratory study, cats artificially infected with adult heartworms and treated with Profender Topical Solution had fewer worms recovered than the placebo control group. The safety index has been derived from controlled safety evaluations, clinical trials and prior approved use in foreign countries. Dosages of 5 times the labeled rate at 14 day intervals to dogs as young as 4 weeks did not produce signs of clinical toxicity following either intramuscular or subcutaneous injections. No significant clinical chemistry, hematological, cholinesterase or histopathological changes occurred. To assure proper dosage, weigh the cat prior to treatment. KEEP OUT OF REACH OF CHILDREN. Consult your veterinarian before administering to sick or pregnant animals. Tapeworms transmitted by fleas will likely reoccur unless measures are taken to control fleas. Protect from direct sunlight. The presence of tapeworms is indicated by the observance of tapeworm segments passed in the cat's feces. Tapeworm segments are white, pinkish-white or yellow-white in colour and are similar in size and shape to flattened grains of rice. The segments are most frequently observed lying on a freshly passed stool. Segments may also be found on the hair around the anus of the animal, or on the animal's bedding. Cats become infected with tapeworms after eating fleas or small animals mice and other rodents which may be infected with tapeworm larvae. Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Repeat dose twice at 2 weeks intervals. What other drugs will affect pyrantel? Other, less serious side effects may be more likely to occur.
All areas where the animal was maintained or in contact with should be thoroughly cleaned with sodium hypochlorite and allowed to dry completely before reuse. The presence of these parasites should be confirmed through identification of parasite eggs in the feces. Stelma FF, Talla I, Sow S, Kongs A, Niang M, Polman K, Deelder AM, Gryseels B "Efficacy and side effects of praziquantel in an epidemic focus of schistosoma mansoni. Broad Spectrum Wormer tablets will remove Tapeworms Dipylidium caninum, Taenia taeniaeformis Hookworms Ancylostoma tubaeforme and Large Roundworms Toxocara cati in kittens and cats. Droncit praziquantel Injectable Cestocide may be administered by either the subcutaneous or intramuscular route to dogs and cats. The intramuscular route may be preferred in dogs due to a brief period of pain that occasionally follows subcutaneous administration. Anaphylactoid reactions were not observed in clinical trials. However, as with any drug an anaphylactoid reaction can occur with this product and should be treated symptomatically if it occurs. Tablets, following the dosing schedule aforementioned and precautions indicated below. Do not apply to broken skin or if hair coat is wet. Cats become infected with large roundworms by swallowing infective eggs, particularly while grooming, or by ingestion of mice that may be infected with larval stages. Post-Approval Experience: Although not all adverse reactions are reported, based on voluntary post-approval reporting, transient ataxia has been reported following the administration of Drontal Tablets for Cats and Kittens. Bayer HealthCare, Bayer Inc. To assure proper dosage, weigh the cat prior to treatment. Select the number of whole or partial tablets needed for the cat from the following table. Use a dose-measuring spoon, cup, or dropper not a regular tablespoon to ensure that you measure the correct dose of medication. Ask your pharmacist where you can get a dose-measuring device if you do not have one. Cats maintained under conditions of constant exposure to parasite infections should have a follow-up fecal examination within 2 to 4 weeks after the first treatment. Tapeworms transmitted by fleas will likely recur unless measures are taken to control fleas.
Praziquantel is used to treat infections caused by Schistosoma worms, which enter the body through skin that has come into contact with contaminated water. Schistosoma worms are found in Africa, South America, Middle Eastern countries, the Caribbean, and parts of Asia. Do not keep tablets or portions of tablets in your mouth; the bitter taste may cause gagging or vomiting. Treatment of family members and other close contacts may be necessary. Pinworm is spread very easily to others in close contact with the infected person. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. Tablets are available in 50 tablet bottles. An injection site study conducted in feeder calves demonstrated that the formulation may induce a transient reaction in the subcutaneous tissue and underlying muscle. No painful responses to administration were observed.
Not for human use. Keep out of reach of children. Dogs infected with E. multilocularis should be treated to prevent exposure of humans to infective eggs and to reduce perpetuation of the parasite's life cycle. Praziquantel may also be used for purposes not listed in this medication guide. What is the most important information I should know about praziquantel? Broad Spectrum Chewable Anthelmintic Tablets for Dogs are available in three tablet sizes. Each size is scored for convenient oral administration. Georgi JR and Georgi ME. 1990. Parasitology for Veterinarians. F. Precipitation may occur due to cold temperature. To redissolve, warm and then shake the vial.
Roundworms and hookworms are controlled by maintaining the cat's environment free of infective eggs and larvae. Feces and soiled litter should be removed on a daily basis to prevent build-up of eggs and larvae in the environment. Plus Anthelmintic Tablets. In addition, 103 dogs and puppies were included in clinical field studies conducted in 5 veterinary clinics at different geographic locations throughout the United States to further evaluate safety and efficacy. These studies included dogs of various sizes, ages and breeds. Data from these studies demonstrated Drontal Plus Anthelmintic Tablets are safe and efficacious for the removal of the parasite species indicated on the label when used as directed. Results obtained in the laboratory and clinical studies indicate small numbers of hookworm or roundworm eggs may be passed in the feces for up to 7 days after treatment although the worms themselves were eliminated. A follow-up fecal examination should be conducted 2 to 4 weeks after treatment to determine the need for retreatment. The inflammatory reaction produced by antigenic substances released from dying cysts frequently involved increased intracranial pressure, seizures, severe headaches, nausea, and vomiting. In areas where Taenia solium was endemic, these reactions may occur as the result of undiagnosed cysticercosis in patients being treated for other parasitic infections. The duration of the reaction differs among patients. Delayed reactions have been reported. Broad Spectrum Anthelmintic Tablets are indicated for removal of Tapeworms Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus, and removal and control of Echinococcus multilocularis. For removal of Hookworms Ancylostoma caninum, Uncinaria stenocephala Ascarids Toxocara canis, Toxascaris leonina and Whipworms Trichuris vulpis in dogs. Tablets contain three active ingredients having different modes of action and spectra of activity. Praziquantel is active against cestodes tapeworms. Praziquantel is absorbed, metabolized in the liver and excreted in the bile. Upon entering the digestive tract from the bile, cestocidal activity is exhibited. You may need to break a praziquantel tablet in order to get the correct dose. Follow your doctor's instructions. Tablets contain three active ingredients having different modes of action and spectra of activity. Praziquantel is active against cestodes tapeworms. Praziquantel is absorbed, metabolized in the liver and excreted in the bile. Upon entering the digestive tract from the bile, cestocidal activity is exhibited. 1 Following exposure to praziquantel, the tapeworm loses its ability to resist digestion by the mammalian host. Because of this, whole tapeworms, including the scolices, are very rarely passed after administration of praziquantel. In many instances only disintegrated and partially digested pieces of tapeworms will be seen in the stool. The majority of tapeworms are digested and are not found in the feces. Enrofloxacin is bactericidal and exerts its antibacterial effect by inhibiting bacterial DNA gyrase a type II topoisomerase thereby preventing DNA supercoiling and replication which leads to cell death. 1 Enrofloxacin is active against Gram-negative and Gram-positive bacteria. Hildreth MB Johnson MD and Kazacos KR. 1991. A Zoonosis of Increasing Concern in the United States. Compendium for Cont. Ed. 135: 727-740. Tapeworms Dipylidium caninum, Taenia taeniaeformis Hookworms Ancylostoma tubaeforme and Large Roundworms Toxocara cati in cats and kittens. Large roundworms and hookworms may be observed in the feces of the cat a day or so after the cat has been treated with Drontal Tablets. The majority of tapeworms, however, are digested and are not found in the feces after treatment. There are no known contraindications against the use of praziquantel or pyrantel pamoate in dogs.
If reinfection with tapeworms, hookworms or large roundworms occurs, treatment with Drontal Tablets may be repeated. Droncit Injectable in field trials. For dogs the majority of these were described as brief pain responses following injections to larger dogs weighing over 50 lbs. The original geographic distribution of E. multilocularis was primarily confined to northern areas of North America. Current evidence indicates migration of the parasite well into the continental United States. RETREATMENT: Steps should be taken to prevent parasite infections, otherwise retreatment will be necessary. Un-blistered whole or partial tablets should be stored in a tightly sealed container. Taste Tabs information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. Profender Topical Solution may be irritating to skin and eyes. Reactions such as facial, tongue and hand swelling have been reported in humans in rare instances. Avoid contact with the application area while it is wet and wash hands thoroughly with soap and warm water after handling. People with known hypersensitivity to butylhydroxyanisole, emodepside or praziquantel should administer the product with caution. If the product accidentally gets into eyes, flush thoroughly with water. May be harmful if swallowed. In case of accidental ingestion or if skin or eye irritation occurs, call a poison control center or physician for treatment advice. Incidental lameness of short duration was observed in all groups, including the saline-treated controls. Domestic dogs living in E. multilocularis endemic areas that roam freely with the opportunity to catch wild rodents are at risk of infection. Pet owners should be advised on how to minimize this risk.
F was statistically significantly greater than the success rate of saline-treated “sick and febrile” pigs. For the control of SRD, mean rectal temperature, mortality one trial and morbidity were statistically significantly lower for enrofloxacin-treated pigs in pens containing a percentage of “sick and febrile” pigs compared to saline-treated pigs. Cats treated with 10 times the highest recommended Drontal dosage during safety studies showed signs of vomition and salivation without other adverse effects. Eighty-three of 85 cats treated with the recommended dosages of Drontal Tablets in a clinical field study did not exhibit any drug related side effects. A temporary loss of appetite was reported for one cat and transient loose stools were observed in a second cat. Large roundworms and hookworms pass eggs in the feces of the cat that can only be observed with the aid of a microscope. DO NOT USE IN PREGNANT ANIMALS. Dogs treated with elevated levels 6 consecutive days with 3 times the labeled dosage rate of the combination of febantel and praziquantel in early pregnancy demonstrated an increased incidence of abortion and fetal abnormalities. This list is not complete and other drugs may interact with praziquantel. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Often, it was unclear if praziquantel, an endogenous reaction to parasites dying from the drug, or symptoms of the infestation caused the reported side effects. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Droncit praziquantel Injectable Cestocide may be administered by either the subcutaneous or intramuscular route to dogs and cats. The recommended dosage of praziquantel varies according to body weight. Smaller animals require a relatively larger dosage. The optimum dosage for each individual animal will be achieved by utilizing the following dosage schedule. Strict hygienic precautions should be taken when handling dogs or feces suspected of harboring E. multilocularis. Infected dogs treated for the first time with Droncit Injectable solution and dogs treated at intervals greater than 28 days may shed eggs in the feces after treatment. The animal should be held in the clinic during this interval and all feces should be incinerated or autoclaved. Profender Topical Solution is indicated for the treatment and control of hookworm infections caused by Ancylostoma tubaeforme adults, immature adults, and fourth stage larvae roundworm infections caused by Toxocara cati adults and fourth stage larvae and tapeworm infections caused by Dipylidium caninum adults and Taenia taeniaeformis adults in cats. Side effects included malaise, headache, dizziness, abdominal discomfort with or without nausea rise in temperature, and urticaria; generally in order of severity. Praziquantel may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Hildreth MB, Johnson MD and Kazacos KR. 1991. A Zoonosis of Increasing Concern in the United States. Compendium for Cont. Ed. 135: 727-740. Safety has not been established in patients younger than 4 years. Large roundworms are white or yellow-white strands 2-7 inches in length similar in size and color to smooth strings of spaghetti that may be observed in the cat's vomit or feces. Cats become infected with large roundworms by swallowing infective eggs, particularly while grooming, or by ingestion of mice that may be infected with larval stages. Certain parasites such as tapeworms and large roundworms are transmitted to the cat after they eat infected rodents. Each Drontal Plus Taste Tabs Tablet for Large Dogs contains 136. Bayer, the Bayer Cross, and Baytril are trademarks of Bayer. Not intended for use in puppies less than four 4 weeks of age. It is possible that some side effects of praziquantel may not have been reported.
Gastrointestinal side effects have included nausea, vomiting, diarrhea, abdominal cramps. Nervous system side effects have included dizziness, drowsiness, insomnia, and headache. Hookworms are small whitish or reddish-brown worms less than one inch in length that live in the intestinal tract and feed on blood. Cats can become infected with hookworms by swallowing infective larvae while grooming or when larvae from the environment burrow through the skin. Cats infected with hookworms may have poor physical condition, dull haircoat, reduced body weight and diarrhea, sometimes with the presence of dark blood. Praziquantel is usually taken 3 times in one day. Your doses should be taken 4 to 6 hours apart on that day. Take this medication with a full glass 8 ounces of water. Diagnosis of E. multilocularis in canids is difficult. The adult tapeworm produces no clinical signs of infection. Tapeworm segments proglottids are usually not observed in the feces. E. multilocularis eggs, observed using microscopic fecal examination procedures, are similar in appearance to the common taeniid species of canids such as Taenia pisiformis. Drugs other than those listed here may also interact with pyrantel. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines. Watt G, White NJ, Padre L, Ritter W, Fernando MT, Ranoa CP, Laughlin LW "Praziquantel pharmacokinetics and side effects in Schistosoma japonicum-infected patients with liver disease. Always consult a healthcare professional for medical advice. Clinical signs of lameness improved after treatment ceased and most animals were clinically normal at necropsy. Domestic dogs living in E. multilocularis endemic areas that roam freely with the opportunity to catch wild rodents are at risk for infection. Pet owners should be advised on how to minimize this risk. Proper restraint of roaming dogs should be encouraged, along with regular treatment with Droncit Injectable solution, following the dosing schedule aforementioned and precautions indicated below.
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Plus Anthelmintic Tablets. In addition, 103 dogs and puppies were included in clinical field studies conducted in 5 veterinary clinics at different geographic locations throughout the United States to further evaluate safety and efficacy. These studies included dogs of various sizes, ages and breeds. Data from these studies demonstrated Drontal Plus Anthelmintic Tablets are safe and efficacious for the removal of the parasite species indicated on the label when used as directed. Plus Tablets are safe and efficacious for the removal of the parasite species indicated on the label when used as directed.
Droncit praziquantel has been tested in breeding and pregnant dogs and cats. No adverse effects were noted. Freedom of Information Summary FOI NADA 133-953 Vercom Paste febantel and praziquantel. Foreign Market Experience: The following adverse events were reported voluntarily during post-approval use of the product in foreign markets: application site reaction hair loss, dermatitis, pyoderma, edema, and erythema salivation, pruritus, lethargy, vomiting, diarrhea, dehydration, ataxia, loss of appetite, facial swelling, rear leg paresis, seizures, hyperesthesia, twitching, and death. Drontal, Bayer and Bayer Cross are registered trademarks of Bayer AG, used under license.
Quinolone-class drugs should be used with caution in animals with known or suspected Central Nervous System CNS disorders. In such animals, quinolones have, in rare instances, been associated with CNS stimulation which may lead to convulsive seizures. Quinolone-class drugs have been shown to produce erosions of cartilage of weight-bearing joints and other signs of arthropathy in immature animals of various species. See Animal Safety section for additional information. No adverse reactions were observed during clinical trials. Anthelmintic Tablets. Dogs receiving up to 5 times the label dosage 35 mg praziquantel, 35 mg pyrantel pamoate and 179 mg febantel per kg of body weight for 3 consecutive days 3 times the label duration showed clinical signs of vomition and non-formed stools. One dog receiving a 3 times labeled dose had elevated SGPT, SGOT, CPK and GGT readings outside of normal range at 6 days post-treatment.
Cats become infected with tapeworms after eating fleas or small mammals rabbits, mice which may be infected with tapeworm larvae. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasites. Some pyrantel side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. The time interval between individual doses should not be less than 4 hours and not more than 6 hours.